Press Release Summary = Myelin/oligodendrocyte glycoprotein (MOG) is a 26- to 28-kDa protein that was first described as a target antigen for the autoimmune demyelination response observed in animals immunized with CNS homogenates.
Press Release Body = It is a member of the immunoglobulin superfamily expressed in the central nervous system (CNS) and located within the MHC. Found on the surface of myelinating oligodendrocytes and external lamellae of myelin sheaths in the CNS, it is thought to be targeted by the autoimmune T cell response in multiple sclerosis (MS). Although this protein is a minor component of myelin proteins, MOG is a potent autoantigen which contributes extensively to the anti-myelin response and primary inflammatory demyelination in autoimmune diseases. Several lines of evidence suggest that autoreactive antibodies are important in MS pathogenesis, however the pathophysiological significance of MOG-specific autoantibodies in MS/EAE is still controversial. Subtle changes in MOG sequences dramatically influence disease susceptibility and T cell responses in vitro.
In its continuing effort to provide research solutions for MS, AnaSpec offers MOG (35 - 55), mouse, rat, a key peptide that induces severe chronic experimental autoimmune encephalomyelitis in transgenic mice. · MOG (35-55), mouse, rat
* For more information about these additional MOG fragments, contact service@anaspec.com
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References: 1. Delarasse, C. et al. J. Clin. Invest. 112, 544 (2003) 2. Pham-Dinh, D. et al. Proc. Natl. Acad. Sci. USA 3 90, 7990 (1993) 3. Carotenuto, A. et al. J. Med. Chem. 44, 2378 (2001) 4. Bernard, CC. et al. J. Mol. Med. 75, 77 (1997) 5. Iglesias, A. Glia 36, 220 (2001) 6. von Budingen, HC. et al. J. Clin. Immunol. 21, 155 (2001)
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